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Vanderbilt Biophotonics Center

Vanderbilt Biophotonics Center
  2. People
  3. Karen Joos

Karen Joos

Research Focus

Applications of optical techniques for sensing and performing ophthalmic surgery. Aparticular emphasis is the use of miniature optical coherence tomography probes forsurgical image guidance.

Lab Aims

The primary aim is to develop and deploy translatablebiophotonics technologies for ophthalmology.A current emphasis is the development and integration of anintraocular OCT probe to improve visualization of structuresduring vitreoretinal and other ophthalmic surgery, as well asthe integration of these imaging probes with surgical tools androbotic-assisted control for precise tissue manipulation. Pastapproaches included; 1) the investigation of an OCT imagingmodality in eyes with elevated IOP and 2) integration ofintraocular endoscopy to improve visualization and facilitateintraocular surgery in eyes with cloudy corneas. Approachesinclude: histology, morphometry, immunohistochemistry,intraocular pressure response, and biomaterial delivery.

Other bench and clinical projects are glaucoma-centeredresearch topics. Research collaborations are ongoing withmultidisciplinary investigators in ophthalmology, engineering,and genetics.

Lab Members

Name Email Role
Jin Hui Shen jin-hui.shen
Research Assistant Professor
Ratna Prasad - Research Assistant, III

Publications

Tarantola RM, Agarwal A, Lu P, Joos KM. Long-term results of combined endoscope-assisted pars planavitrectomy and glaucoma tube shunt surgery. Retina, 31(2):275-283, 2011. PMCID: PMC3058695.

Kozub J, Ivanov B, Jayasinghe A, Prasad R, Shen J, Klosner M, Heller D, Mendenhall M, Piston D, Joos K,Hutson MS. Raman-shifted alexandrite laser for soft tissue ablation in the 6- to 7-m wavelength range.Biomedical Optic Express, 2(5):1275-1281, 2011. PMCID: PMC3087584.

Yu H, Shen JH, Joos K, and Simaan N. Design, calibration and preliminary testing of a robotictelemanipulator for OCT-guided retinal surgery. IEEE International Conference Proceedings on Roboticsand Automation (ICRA'2013), peer-reviewed paper, 2013: 225–231.

Joos KM, Shen JH. Miniature real-time intraoperative forward-imaging optical coherence tomographyprobe. Biomedical Optics Express, 4(8):1342-1350, 2013. PMCID: PMC3756577.

Li Z, Shen J, Kozub J, Prasad R, Lu P, Joos K, A miniature forward-imaging B-scan optical coherencetomography probe to guide real-time laser ablation. Lasers in Surgery and Medicine, 46(3):193-202,2014. PMCID: PMC3962956.

Joos KM, Shen J. Preliminary design and evaluation of a B-scan OCT-guided 36-gauge needle tip.Photonics, 1: 260-266; doi:10.3390/photonics1030260, 2014.

Yu H, Shen J, Shah R, Simaan N, Joos KM. Evaluation of microsurgical tasks with OCT-guided and/orrobot-assisted ophthalmic forceps. Biomedical Optics Express, 6(2): 457–472, 2015. PMID: 25780736.

Kozub JA, Shen JH, Joos KM, Prasad R, Hutson S. Efficacy and predictability of soft tissue ablation using aprototype Raman-shifted alexandrite laser. J Biomedical Optics, 20(10):105004. doi:10.1117/1.JBO.20.10.105004. PMID: 26456553.

Kozub J, Shen J, Joos KM, Prasad R, Hutson MS, Optic nerve sheath fenestration using a Raman-shiftedalexandrite laser. Lasers in Surgery and Medicine, 48(3):270-280, 2016, doi: 10.1002/lsm.22456. PMID:27020001, PMC: 820007. --- Journal Cover Photo

Choh V, Gurdita A, Tan B, Prasad RC, Bizheva K, Joos KM. Short-term moderately elevated intraocularpressure is associated with elevated scotopic electroretinogram responses. Investigative Ophthalmologyand Visual Science, 2016; 57(4): 2140-2151. doi: 10.1167/iovs.15-18770. PMID: 27100161.

Yu H, Shen JH, Joos KM, Simaan N. Calibration and integration of B-mode optical coherence tomographyfor assistive control in robotic micro-surgery. Transactions in Mechatronics. 2016 June 22. [Epub aheadof print], 2016; 21(6):2613-2623. doi: 10.1109/TMECH.2016.2583259.
http://ieeexplore.ieee.org/document/7496970/.


Malone JD, El-Haddad MT, Bozic I, Tye LA, Majeau L, Godbout N, Rollins AM, Boudoux C, Joos KM, PatelSN, Tao YK. Simultaneous multimodal ophthalmic imaging using swept-source spectrally encodedscanning laser ophthalmoscopy and optical coherence tomography. Biomed Opt Express. 2017;8(1):193-206. doi: 10.1364/BOE.8.000193. PMID: 28101411.

Del Giudice G, Wang L, Shen JH, Joos K, Simaan N. Continuum Robots for Multi-Scale Motion: Micro-Scale Motion through Equilibrium Modulation. Proceedings of the 2017 IEEE/RSJ InternationalConference on Intelligent Robots and Systems (IROS 2017). Sept 2017, doi: 10.1109/IROS.2017.8206074.

Tan B, Gurdita A, Choh V, Joos K, Prasad R, Bizheva K. Morphological and functional changes in the ratretina associated with 2 months of intermittent moderate intraocular pressure elevation. ScientificReports. 2018; 8:7727 (1-11) . doi:10.1038/s41598-018-25938-zwww.nature.com/articles/s41598-018-25938-z, PMID: 29769654.